Amarin troubles grow as fish oil shows no benefits

The supplement has no heart benefits for patients, which doesn't bode well for the drug company's efforts to market Vascepa.

By TheStreet Staff May 9, 2013 11:18AM

thestreet logo

Pills © SuperStockBy Adam Feuerstein


A large study has once again demonstrated the failure of fish oil supplements to reduce heart disease or death in patients at higher risk for heart disease. The negative results of the Italian Risk and Prevention Study, published Wednesday in the New England Journal of Medicine, could not come at a worse time for Amarin (AMRN) and its prescription fish oil pill Vascepa.


Amarin is already struggling to convince doctors and patients to try Vascepa, so the last thing the company needs is more definitive clinical evidence ripping apart the theory that daily fish oil intake leads to improved heart health.


Vascepa was not used in the Italian study published Wednesday, but still, the odds of Amarin convincing a large pharmaceutical company to partner up on Vascepa's marketing or acquire the entire company went from low to nearly impossible.


Amarin will release first-quarter financial results and hold an investor conference call after the close of regular trading Thursday. Street consensus for Vascepa first-quarter sales is $3.65 million, according to Bloomberg.


The Italian Risk and Prevention Study enrolled 12,513 patients with multiple cardiovascular risk factors or evidence of heart disease but no prior history of heart attacks. Half the patients were randomized to receive 1 gram per day of n-3 fatty acids (fish oil) or an olive oil placebo.


After five years of follow up, 11.7% of the patients taking daily fish oil died or were hospitalized due to cardiovascular disease compared to 11.9% of patients treated with a placebo. There was also no difference in any of the prospective secondary endpoints.


"On the basis of the results, we conclude that there was no significant benefit of n-3 fatty acids in reducing the risk of death from cardiovascular causes or hospital admission for cardiovascular causes," the researchers conclude.


Eric Topol, a well-known cardiologist at the Scripps Clinic who was not involved in the study, was even more blunt in comments made to TheHeart.org.


"Fish oil does nothing," said Topol. "We can't continue to argue that we didn't give the right dose or the right preparation. It is a nada effect."


Amarin supporters were quick to defend Vascepa Wednesday night, with some taking to Twitter to argue the negative findings from the fish oil supplement study had no bearing on Vascepa because it contains more fish oil manufactured at a higher purity.


Amarin executives will likely make the same argument if/when they're asked to comment on the Italian study during tonight's conference call.


But in the Italian study, daily use of the fish oil supplement resulted in a statistically significant reduction in triglycerides, a type of fat found in the blood believed to have a negative effect on heart health. This is exactly what Vascepa does and is the basis for the pill's approval last year.


Yet now we have another study showing fish oil's role in lowering triglyceride levels, which is only a laboratory measurement, doesn't help patients avoid heart disease or reduce heart-related deaths, not even a little bit.


The evidence against fish oil's benefits is growing, and Amarin will have a hard time explaining why Vascepa, even at a higher dose, should perform any better.


More from TheStreet.com

2Comments
May 9, 2013 3:35PM
avatar

Amarin is NOT a fish oil company.  Also, I didn't see Mr Feuerstein's disclaimer that he is a SHORT holder of Amarin stock.  Very deceptive and manipulative story.

 

Jul 12, 2013 6:59PM
avatar

Fish oil saved my life,after suffering for decades with hypertriglyceridelipedemia (3000+) with no help from statins (can't tolerate them) my triglycerides in 6 months dropped to 400 (now 235) and i just had PSA (excellent) so ,i'm sticking with it

Report
Please help us to maintain a healthy and vibrant community by reporting any illegal or inappropriate behavior. If you believe a message violates theCode of Conductplease use this form to notify the moderators. They will investigate your report and take appropriate action. If necessary, they report all illegal activity to the proper authorities.
Categories
100 character limit
Are you sure you want to delete this comment?

DATA PROVIDERS

Copyright © 2014 Microsoft. All rights reserved.

Fundamental company data and historical chart data provided by Morningstar Inc. Real-time index quotes and delayed quotes supplied by Morningstar Inc. Quotes delayed by up to 15 minutes, except where indicated otherwise. Fund summary, fund performance and dividend data provided by Morningstar Inc. Analyst recommendations provided by Zacks Investment Research. StockScouter data provided by Verus Analytics. IPO data provided by Hoover's Inc. Index membership data provided by Morningstar Inc.

STOCK SCOUTER

StockScouter rates stocks from 1 to 10, with 10 being the best, using a system of advanced mathematics to determine a stock's expected risk and return. Ratings are displayed on a bell curve, meaning there will be fewer ratings of 1 and 10 and far more of 4 through 7.

126
126 rated 1
286
286 rated 2
474
474 rated 3
680
680 rated 4
626
626 rated 5
609
609 rated 6
620
620 rated 7
462
462 rated 8
304
304 rated 9
132
132 rated 10
12345678910

Top Picks

SYMBOLNAMERATING
AAPLAPPLE Inc10
BIDUBAIDU Inc10
BXTHE BLACKSTONE GROUP L.P10
CELGCELGENE CORP10
FOXATWENTY-FIRST CENTURY FOX Inc CLASS A10
More

VIDEO ON MSN MONEY

ABOUT

Top Stocks provides analysis about the most noteworthy stocks in the market each day, combining some of the best content from around the MSN Money site and the rest of the Web.

Contributors include professional investors and journalists affiliated with MSN Money.

Follow us on Twitter @topstocksmsn.